Reduced expression of sushi domain containing 2 is associated with progression of non-small cell lung cancer

Autor:	Yuan Gao, Jun Zeng, Rong Shi, Wen-Ling Zheng, Wen-Li Ma, Cuixia Cai, Min Wei, Handuo Wang
Rok vydání:	2015
Předmět:	Sushi domain Cancer Research Pathology medicine.medical_specialty Tissue microarray Oncogene Cancer Articles Cell cycle Biology medicine.disease Molecular medicine Oncology Cancer research medicine Immunohistochemistry Lung cancer
Zdroj:	Oncology Letters. 10:3619-3624
ISSN:	1792-1082 1792-1074
DOI:	10.3892/ol.2015.3737
Popis:	Sushi domain containing 2 (SUSD2) has been identified as a gene encoding an 822-amino acid protein, which contains a transmembrane domain and functional domains inherent to adhesion molecules. Previous studies have reported that increased expression of SUSD2 has a critical role in tumorigenesis in human breast cancer. However, to the best of our knowledge, SUSD2 expression status and its correlation with the clinicopathological features of non-small cell lung cancer (NSCLC) have not previously been investigated. In the present study, reverse transcription-quantitative polymerase chain reaction and western blotting were used to evaluate SUSD2 messenger RNA (mRNA) and protein expression in NSCLC and adjacent normal lung tissues. The clinicopathological significance of SUSD2 was investigated by immunohistochemical analysis of an NSCLC tissue microarray. Receiver operating characteristic analysis was used to determine the cut-off score for positive expression of SUSD2. Furthermore, the correlation between SUSD2 expression and the clinicopathological features of NSCLC was analyzed by χ2 test. The results revealed that SUSD2 mRNA (P47.5% (area under ROC curve, 0.799; P
Databáze:	OpenAIRE
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