Immunological Predictors of Dimethyl Fumarate-Induced Lymphopenia

Autor: Diebold, Martin, Galli, Edoardo, Kopf, Andreas, Sanderson, Nicholas, Callegari, Ilaria, Ingelfinger, Florian, Gonzalo Núñez, Nicolás, Benkert, Pascal, Kappos, Ludwig, Kuhle, Jens, Becher, Burkhard, Claassen, Manfred, Derfuss, Tobias
Jazyk: angličtina
Rok vydání: 2022
Zdroj: Annals of Neurology, 91 (5)
ISSN: 0364-5134
1531-8249
DOI: 10.3929/ethz-b-000538280
Popis: Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune markers of DMF-associated lymphopenia. This prospective observational study longitudinally assessed 31 individuals with MS by single-cell mass cytometry before and after 12 and 48 weeks of DMF therapy. Employing a neural network-based representation learning approach, we identified a CCR4-expressing T helper cell population negatively associated with relevant lymphopenia. CCR4-expressing T helper cells represent a candidate prognostic biomarker for the development of relevant lymphopenia in patients undergoing DMF treatment. ANN NEUROL 2022
Annals of Neurology, 91 (5)
ISSN:0364-5134
ISSN:1531-8249
Databáze: OpenAIRE
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