Mechanism of stem cells in the central nervous system
| Autor: | Clas B. Johansson |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Central Nervous System
Physiology Mechanism (biology) Stem Cells Regeneration (biology) Clinical Biochemistry Central nervous system Cell Biology Biology Spinal cord Neural stem cell Cell therapy Transplantation medicine.anatomical_structure Immunology medicine Animals Humans Stem cell Neuroscience Stem Cell Transplantation |
| Zdroj: | Journal of Cellular Physiology. 196:409-418 |
| ISSN: | 1097-4652 0021-9541 |
| DOI: | 10.1002/jcp.10293 |
| Popis: | Injury to the central nervous system (CNS) can result in severe functional impairment. The brain and spinal cord, which constitute the CNS, have been viewed for decades as having a very limited capacity for regeneration. However, over the last several years, the body of evidence supporting the concept of regeneration and continuous renewal of neurons in specific regions of the CNS has increased. This evidence has significantly altered our perception of the CNS and has offered new hope for possible cell therapy strategies to repair lost function. Transplantation of stem cells or the recruitment of endogenous stem cells to repair specific regions of the brain or spinal cord is the next exciting research challenge. However, our understanding of the existing stem cell pool in the adult CNS remains limited. This review will discuss the identification and characterization of CNS stem cells in the adult brain and spinal cord. |
| Databáze: | OpenAIRE |
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