A TRAF6 genetic variant is associated with low bone mineral density in rheumatoid arthritis
| Autor: | Hana Ben Hassine, Ramzi Zemni, Imen Ben Nacef, Khadija Baccouche, Asma Boumiza, Zahid Shakoor, Elyes Bouajina, Foued Slama, Rim Sghiri, Sarra Melayah, Najla Amri, Adel Almogren |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Osteoporosis Single-nucleotide polymorphism Gastroenterology Polymorphism Single Nucleotide Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Absorptiometry Photon Rheumatology Gene Frequency Bone Density Risk Factors Internal medicine Medicine Humans 030212 general & internal medicine Femur Risk factor Alleles Aged 030203 arthritis & rheumatology Bone mineral TNF Receptor-Associated Factor 6 Lumbar Vertebrae business.industry Femur Neck Confounding General Medicine Middle Aged medicine.disease Osteopenia Rheumatoid arthritis Female business |
| Zdroj: | Clinical rheumatology. 38(4) |
| ISSN: | 1434-9949 |
| Popis: | This study was aimed to investigate the association of the single nucleotide polymorphism of tumor necrosis factor receptor associated factor 6 (TRAF6), rs540386, with low bone mineral density (BMD) among patients with rheumatoid arthritis (RA). TRAF6 rs540386 genotyping was performed by mutagenically separated PCR in a cohort of 188 (23 men, 165 women, median age, 56.2 years) adult RA patients and 224 age and gender-matched controls. BMD was measured using dual-energy X-ray absorptiometry (DXA) (Lunar Prodigy advance scans, GE Healthcare, USA). Among the RA patients, 64 (55 women, 9 men) had low BMD comprising of 57 patients with osteoporosis and 7 with osteopenia. Whereas TRAF6 rs540386 was not associated with RA susceptibility, it was however found to be a risk factor for reduced lumbar spine Z-score in the recessive model (OR = 3.34, 95% CI = (1.01–11.00), p = 0.038). This association was confirmed further in the multivariate logistic regression analysis taking into account several potential confounding factors (OR = 3.34 (1.01–11.00), p = 0.048). In addition, mean total femur Z-score was found to be reduced in TT patients when compared to CC + CT patients (− 1.30 ± 1.32 versus − 0.60 ± 1.05, p = 0.034). No association between TRAF6 rs540386 and local bone damage was observed. This study for the first time ever demonstrated an association between a genetic variant of TRAF6 and low BMD among patients with RA. Further investigations are needed to elucidate the exact role of this variant. |
| Databáze: | OpenAIRE |
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