Fibroblast Growth Factor 21 and Its Association With Oxidative Stress and Lipid Profile in Type 2 Diabetes Mellitus
| Autor: | Abdul Subhan Talpur, Hassan Abdullah Shakeel, Ahmed F Zafar, Shifa Younus, Hamza Maqsood, Mudassar Aleem |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
FGF21 Cardiology Type 2 diabetes lipids chemistry.chemical_compound Internal medicine fibroblast growth factor medicine Internal Medicine oxidative stress medicine.diagnostic_test Cholesterol business.industry dyslipidemia General Engineering Endocrinology/Diabetes/Metabolism Type 2 Diabetes Mellitus medicine.disease Endocrinology Glycemic index chemistry Glycated hemoglobin type 2 diabetes Metabolic syndrome Lipid profile business |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Introduction Cardiovascular diseases are the leading cause of mortality in diabetic patients. Oxidative stress and mitochondrial dysfunction lead to diabetic cardiomyopathy (DCM) characterized by impaired cardiac structure and function. Hyperglycemia causes oxidative stress, which can lead to microvascular complications, macrovascular complications, and atherosclerosis. Peripheral tissues produce fibroblast growth factor 21 (FGF-21), which has anti-inflammatory properties, increases oxidation of fatty acids, and improves insulin sensitivity. Its increased levels are found in metabolic syndrome and type 2 diabetes mellitus and may also lead to coronary heart disease. Our study sought to measure the serum FGF-21 levels and their associations with lipid profile parameters and oxidative stress in patients with type 2 diabetes mellitus. Methodology One-hundred fifty (150) patients of both genders with type 2 diabetes mellitus were recruited along with 150 controls. Simple random sampling was done. After taking relevant history and physical examination, we drew venous blood samples of each patient and sent them to the institutional laboratory for analysis of fasting blood sugar (FBS) levels, glycated hemoglobin (HbA1C), lipid profile, and FGF-21 serum levels. Oxidative stress parameter malondialdehyde (MDA) was estimated and the total antioxidant status by ferric reducing antioxidant power assay (FRAP) was assessed. Patients were followed up after three months to record the glycemic index, and the values were recorded. We used SPSS Software 25.0 (SPSS, Inc., Chicago, USA) to analyze the data. For consideration of results to be statistically significant, a 𝑃 value of < 0.05 was selected. Results The levels of serum cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol were increased in diabetics compared to controls and were statistically significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|