Role of Kinase Epidermal Growth Factor Receptor and SRC in the Caerulein-Induced Acute Pancreatitis in Mice
| Autor: | Dongbo Xue, Weiliang Xia, Yingmei Zhang, Ming Lu, Bei Sun, Weihui Zhang, Xin Qiao, Yongming Huang, Bo Gao |
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| Rok vydání: | 2015 |
| Předmět: |
TGF alpha
Endocrinology Diabetes and Metabolism Biology Tropomyosin receptor kinase C Gene Expression Regulation Enzymologic Endocrinology Databases Genetic Internal Medicine Animals Gene Regulatory Networks Protein Interaction Maps RNA Messenger Protein kinase A Protein Kinase Inhibitors Oligonucleotide Array Sequence Analysis Insulin-like growth factor 1 receptor Hepatology Kinase Gene Expression Profiling Cell biology ErbB Receptors Disease Models Animal src-Family Kinases Pancreatitis Acute Disease Signal transduction Tyrosine kinase Ceruletide Signal Transduction Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | Pancreas. 44:152-157 |
| ISSN: | 0885-3177 |
| Popis: | Objectives In this study, we identified the protein kinases that play the most distinct roles in the occurrence of acute pancreatitis (AP). Methods Gene expression profile data were downloaded from Gene Expression Omnibus database (GSE3644). The sample was from caerulein-induced AP mice. The intersection of the differentially expressed genes in AP mice taken from a protein kinase database was obtained for screening of the protein kinase encoded genes that were differentially expressed. Database for annotation, visualization, and integrated discovery was used for the functional enrichment analysis. Kinase inhibitors that regulated these kinases were retrieved from PubMed through text mining. Results Twenty-nine differentially expressed kinase encoded genes were identified through screening. The functional enrichment analysis demonstrated that the functions of these genes were primarily enriched in "mitogen-activated protein kinase signaling pathway," followed by "extracellular regulated protein kinases pathway," "neurotrophin signaling pathway," "adherens junction," and "gap junction." SRC and epidermal growth factor receptor (EGFR) were related to extracellular regulated protein kinases pathway and also related to adherens junction as well as gap junction. On the basis of the regulated kinases, the kinase inhibitors reported in the literature were classified into multiple groups. Conclusions EGFR and SRC may be coexpressed in AP. The kinase inhibitors working together in SRC and EGFR may play better efficacy in the treatment of AP. |
| Databáze: | OpenAIRE |
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