Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
| Autor: | Justin D. Radolf, Ruey-Bing Yang, Gary R. Klimpel, Arturo Zychlinsky, Paul J. Godowski, Shelly Suggett, Brigitte Devaux, Melanie R. Mark, Antonios O. Aliprantis |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Cytotoxicity
Immunologic Lipopolysaccharides Programmed cell death Lipoproteins Lipopolysaccharide Receptors Inflammation Apoptosis Receptors Cell Surface Biology Transfection Monocytes Cell Line Bacterial Proteins Genes Reporter medicine Tumor Cells Cultured Drosophila Proteins Humans Cycloheximide Protein Synthesis Inhibitors Toll-like receptor Multidisciplinary Innate immune system Membrane Glycoproteins Monocyte Toll-Like Receptors NF-kappa B Antibodies Monoclonal Toll-Like Receptor 2 Respiratory burst Cell biology medicine.anatomical_structure Immunology Tetradecanoylphorbol Acetate medicine.symptom Cell activation Reactive Oxygen Species Signal Transduction |
| Zdroj: | Science (New York, N.Y.). 285(5428) |
| ISSN: | 0036-8075 |
| Popis: | Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial pathogens. All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor–2 (hTLR2). BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2. In addition, BLPs stimulated nuclear factor–κB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2. Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms. |
| Databáze: | OpenAIRE |
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