Rectum cancers with distant metastases (Stage IV) show decreased tissue expression of E cadherin at the invasive tumor front

Autor:	Mehmet Zengin, Pınar Atasoy
Rok vydání:	2020
Předmět:	medicine.medical_specialty Univariate analysis business.industry Cadherin Hazard ratio General Medicine Rectum Cancers Gastroenterology E cadherin rectal cancer prognostic markers Tissue expression Internal medicine medicine Lymph Stage (cooking) business Stage iv
Zdroj:	Volume: 53, Issue: 1 12-19 Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi
ISSN:	1304-6187
DOI:	10.20492/aeahtd.571124
Popis:	Aim: Rectal cancers (RC) are one of the most cause of death worldwide. Survival of patients is mainly associated with the TNM stage. However, patients characterized by the same tumor stage often have prominent distinct survival. This is particularly a clinical challenge and new biomarkers are needed. In the present research, we analyzed the prognostic role of E-cadherin (EC) in stage IV RC. Methods: Eighty-five stage IV RC patients who underwent surgery at Kırıkkale University during 2001–2015 were included in this retrospective study. EC was scored on immunohistochemical (IHC) stained sections with a cut-off value of ≥50% ratio. The relationship between the results and the clinicopathological characteristics was analyzed. Results: EC percentage was significantly downregulated in RCs classified as advanced pT (p= 0.005), angiolymphatic invasion (p= 0.034), advanced stage (p=0.006), high number of metastatic lymph nodes (p=0.039) and high grade (p=0.014). In univariate analysis, low EC patients had worse 5-year survival (RFS: 28.3%, p
Databáze:	OpenAIRE
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