Prostaglandin E2 Content in Herniated Lumbar Disc Disease
| Autor: | O'Donnell Al, O'Donnell Jl |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.medical_treatment Lumbar vertebrae Dinoprostone Sciatica Internal medicine medicine Humans Orthopedics and Sports Medicine Prostaglandin E2 Intervertebral Disc Leg Lumbar Vertebrae business.industry Intervertebral disc medicine.disease Low back pain Intervertebral disk Endocrinology medicine.anatomical_structure lipids (amino acids peptides and proteins) Neurology (clinical) medicine.symptom business Low Back Pain Intervertebral Disc Displacement Lumbar disc disease Prostaglandin E medicine.drug |
| Zdroj: | Spine. 21:1653-1655 |
| ISSN: | 0362-2436 |
| Popis: | Study Design. A prospective series of biochemical assays for prostaglandin E 2 content in symptomatic herniated lumbar disc specimens. Objectives. The help clarify the pathogenesis of lumbar radiculopathy. Summary of Background Data. Three recent studies have shown elevated levels of prostaglandin E 2 in intervertebral disc herniations. None of these studies correlated symptoms with prostaglandin E 2 levels. Methods. Twenty-four disrupted disc samples were purified by a standard solid phase extraction method and analyzed for prostaglandin E 2 with an enzyme-linked immunosorbent assay. Clinical and anatomic correlations were sought with analysis of variance and t test. Results. Sequestered discs tended to be associated with a higher prostaglandin E 2 content than extruded discs, which in turn, tended to be associated with higher prostaglandin E 2 content than protruded ones. A positive straight leg raising test appeared to be associated with a higher prostaglandin E 2 content than a negative test. Conclusions. Prostaglandin E 2 appears to mediate some of the inflammatory effects of lumbar disc herniation. An intact anulus may provide some protection against this stimulus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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