Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells
| Autor: | S G Irving, Ulrich Siebenlist, Hiroaki Mitsuya, Kurt C. Gunter, John J. Wright, Kathleen Kelly |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Gene Expression Regulation
Viral Genes Viral viruses T cell T-Lymphocytes Molecular Sequence Data Cell Line Transactivation Gene expression Metalloproteins medicine Humans Amino Acid Sequence Gene Zinc finger Viral Structural Proteins Human T-lymphotropic virus 1 Multidisciplinary biology Human T-lymphotropic virus 2 biology.organism_classification Cell Transformation Viral Virology Cell biology DNA-Binding Proteins Zinc medicine.anatomical_structure Cell culture |
| Zdroj: | Science (New York, N.Y.). 248(4955) |
| ISSN: | 0036-8075 |
| Popis: | Gene products encoded by the human T cell leukemia virus (HTLV) types I and II mediate transformation by the transactivation of cellular genes necessary for proliferation, probably including transcriptional regulatory factors. By searching for factors that may control proliferation, a zinc finger gene (225) was identified that was constitutively expressed in all HTLV-I- or HTLV-II-transformed cell lines examined, whereas in normal T cells it was only transiently expressed after mitogenic stimulation. The 225 gene was also constitutively expressed in two HTLV-I-transformed helper T cell clones, but not in the parental cell lines. Thus this putative cellular transcriptional factor, which was abnormally expressed in retrovirus-infected cells, may have a role in transformation. |
| Databáze: | OpenAIRE |
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