| Autor: |
Arifa Parker, Linda Boloko, Muhammad S. Moolla, Nabilah Ebrahim, Birhanu T. Ayele, Alistair G. B. Broadhurst, Boitumelo Mashigo, Gideon Titus, Timothy de Wet, Nicholas Boliter, Michael-Jon Rosslee, Nectarios Papavarnavas, Riezaah Abrahams, Marc Mendelson, Sipho Dlamini, Jantjie J. Taljaard, Hans W. Prozesky, Abdurasiet Mowlana, Abraham J. Viljoen, Neshaad Schrueder, Brian W. Allwood, Usha Lalla, Joel A. Dave, Greg Calligaro, Dion Levin, Deborah Maughan, Ntobeko A. B. Ntusi, Peter S. Nyasulu, Graeme Meintjes, Coenraad F. N. Koegelenberg, Ayanda T. Mnguni, Sean Wasserman |
| Přispěvatelé: |
Department of Medicine, Faculty of Health Sciences |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
BMC Infectious Diseases |
| ISSN: |
1471-2334 |
| Popis: |
Background There is still a paucity of evidence on the outcomes of coronavirus disease 2019 (COVID-19) among people living with human immunodeficiency virus (PWH) and those co-infected with tuberculosis (TB), particularly in areas where these conditions are common. We describe the clinical features, laboratory findings and outcome of hospitalised PWH and human immunodeficiency virus (HIV)-uninfected COVID-19 patients as well as those co-infected with tuberculosis (TB). Methods We conducted a multicentre cohort study across three hospitals in Cape Town, South Africa. All adults requiring hospitalisation with confirmed COVID-19 pneumonia from March to July 2020 were analysed. Results PWH comprised 270 (19%) of 1434 admissions. There were 47 patients with active tuberculosis (3.3%), of whom 29 (62%) were PWH. Three-hundred and seventy-three patients (26%) died. The mortality in PWH (n = 71, 26%) and HIV-uninfected patients (n = 296, 25%) was comparable. In patients with TB, PWH had a higher mortality than HIV-uninfected patients (n = 11, 38% vs n = 3, 20%; p = 0.001). In multivariable survival analysis a higher risk of death was associated with older age (Adjusted Hazard Ratio (AHR) 1.03 95%CI 1.02–1.03, p 3, higher admission oxygen requirements, absolute white cell counts, neutrophil/lymphocyte ratios, C-reactive protein, and creatinine levels. Conclusion In a population with high prevalence of HIV and TB, being overweight/obese was associated with increased risk of mortality in COVID-19 hospital admissions, emphasising the need for public health interventions in this patient population. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink