Synthesis, characterization of thiosemicarabzone metal complexes and antioxidant activity in different in vitro model systems
| Autor: | Seung-Mok Lee, Kalluru Seshaiah, Kumar Reddy Harikishore, K Ramesh Babu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Stereochemistry
DPPH Ligand Conductance antioxidant activity bimetallic complexes General Chemistry Medicinal chemistry Decomposition Chloride spectral analysis transition metal complexes Metal lcsh:Chemistry chemistry.chemical_compound thiosemicarbazone chemistry lcsh:QD1-999 visual_art visual_art.visual_art_medium medicine Molecule Semicarbazone medicine.drug |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 78, Iss 2, Pp 229-240 (2013) |
| ISSN: | 0352-5139 |
| Popis: | The synthesis of bi metallic Cu(II), Co(II), Ni(II) , Zn(II) and U(VI) complexes with general st oichiometry ( H2L M(X2)(H2O)2) (where H 2L is the di-deprotanated ligand and X is chloride/ sulphate) were obta ined with the li- gand terephthaladehyde bis(thi osemicarbazone) (H 2L) and are discu ssed. The ligand and it s binuclear co mplexes were characterized b y m icro a nalysis (CHNS), 1 H-NMR, FT-IR, UV-vis, TG-DTA and conductance measurements. The thermal behaviour of these complexes showed that the hydrated complexes loose wat er molecules of hydration in the first ste p, followed i mmediately by decomposition of the anions and ligand molecules in the subsequent steps. The molar conductance measurements of the complexes in DMF correspond to t he non-electrolytic nature of the c omplexes. Furthermore, the an tioxidant activity of the ligand and its complexes w ere det ermined in vit ro by the hy droxyl radical sc avenging, DPPH, NO and reducin g power methods. The obtain ed IC50 value of the DPPH a ctivity for complex 2 (IC50 = 0.254 M) was shown to be the best. |
| Databáze: | OpenAIRE |
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