Clinical Experience, Characteristics, and Performance of an Acetaminophen Absorption Test in Critically Ill Patients
| Autor: | Molly E. Droege, Eric W. Mueller, Daniel R Mosher, Aaron M Swomley, Abigail G Rhoades, Christopher A. Droege, Neil Ernst |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Drug congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Surrogate endpoint business.industry media_common.quotation_subject Gastric motility General Medicine Absorption (skin) Enteral administration Acetaminophen Internal medicine Intensive care medicine Pharmacology (medical) business medicine.drug media_common Cohort study |
| Zdroj: | American journal of therapeutics. |
| ISSN: | 1536-3686 |
| Popis: | BACKGROUND Altered drug and nutrient absorption presents a unique challenge in critically ill patients. Performing an acetaminophen absorption test (AAT) has been used as a marker for gastric motility and upper small bowel absorption; thus, it may provide objective data regarding enteral absorptive ability in critically ill patients. STUDY QUESTION What is the clinical experience with AAT when used as a surrogate marker for enteral absorption in critically ill patients? STUDY DESIGN This single-center, retrospective, cohort study evaluated serum acetaminophen concentrations within 180 minutes following 1-time enteral administration of an AAT. Patients admitted to the surgical and medical intensive care units and medical intensive care units over a 7-year period were evaluated. Groups were defined as positive (acetaminophen concentration of ≥10 mg/L) or negative (acetaminophen concentration of |
| Databáze: | OpenAIRE |
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