Alzheimer disease and vascular dementia: relationships with fasting glucose and insulin levels
| Autor: | Giovanni Zuliani, Anna Solini, E. Palmieri, Renato Fellin, K. D'Elia, M. Carantoni |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Cognitive Neuroscience medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Fasting glucose chemistry.chemical_compound Insulin resistance Alzheimer Disease Internal medicine DEMENTIA ALZHEIMER FASTING GLUCOSE INSULIN RESISTANCE medicine Dementia Humans Insulin Vascular dementia Aged Aged 80 and over business.industry Cholesterol Dementia Vascular Cholesterol HDL medicine.disease Psychiatry and Mental health Endocrinology chemistry Uric acid Female Geriatrics and Gerontology Alzheimer's disease Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Dementia and geriatric cognitive disorders. 11(3) |
| ISSN: | 1420-8008 |
| Popis: | Cerebrovascular disease and Alzheimer disease are the leading causes of dementia in elderly subjects. In spite of it, relatively little is known about the pathogenesis and risk factors for dementia. We evaluated fasting plasma glucose and insulin, albumin, lipids, Lp(a) and uric acid levels in nondiabetic patients of both sexes affected by vascular dementia (VD) and senile dementia of the Alzheimer type (SDAT) as well as in a control group of age-matched nondemented subjects. Following a covariance analysis by gender, body mass index, albumin levels and prevalence of arterial hypertension, total and LDL cholesterol as well as HDL cholesterol levels were not significantly different among the three groups. Fasting glucose (p < 0.001 and p < 0.005, respectively) and insulin levels (p < 0.05 for both differences) were higher in patients with VD and SDAT than in control subjects. Our data show that nondiabetic patients with VD or SDAT have higher fasting glucose and insulin levels than healthy control subjects. These metabolic characteristics were not influenced by differences in gender, adiposity, nutritional status, lipids or presence of arterial hypertension. |
| Databáze: | OpenAIRE |
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