Umbilical cord levels of sclerostin, placental weight, and birth weight are predictors of total bone mineral content in neonates
| Autor: | Jens Bollerslev, Kathrine Frey Frøslie, Kristin Godang, Tove Lekva, Nanna Voldner, Thor Ueland, Tore Henriksen, Gunhild A. Isaksen |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Genetic Markers
Male medicine.medical_specialty Bone density Endocrinology Diabetes and Metabolism Birth weight Pregnancy Trimester Third Context (language use) Biology Umbilical cord Bone and Bones Cohort Studies Fetal Development chemistry.chemical_compound Endocrinology Absorptiometry Photon Bone Density Pregnancy Internal medicine Placenta medicine Birth Weight Humans Prospective Studies Klotho Proteins Adaptor Proteins Signal Transducing Glucuronidase Fetus Bone Development Infant Newborn General Medicine Organ Size medicine.disease Fetal Blood Placentation Fibroblast Growth Factor-23 medicine.anatomical_structure chemistry Bone Morphogenetic Proteins Sclerostin Female Biomarkers |
| Zdroj: | European journal of endocrinology. 168(3) |
| ISSN: | 1479-683X |
| Popis: | ContextDuring pregnancy, changes occur in the maternal calcium homeostasis to fulfill fetal demand. We hypothesized that the fibroblast growth factor 23 (FGF23) system and Wnt signaling pathway are important for normal skeletal development in the offspring.AimsCirculating α-klotho, FGF23, sclerostin, and 25-hydroxyvitamin D (25(OH)D) at the fetal and maternal sides of the placenta were measured to investigate associations with newborn bone mass independent of maternal BMI, calcium and phosphate levels, placental weight, and birth weight.MethodsIn a prospective cohort of healthy pregnant women, the total body bone mineral content (BMC) in 202 newborns was measured by dual-energy X-ray absorptiometry. Maternal circulating levels of the biomarkers were measured at gestational weeks 30–32 and in umbilical cord plasma (UCP) at birth.ResultsMean α-klotho and sclerostin concentrations in the UCP were significantly higher than maternal levels (3004 vs 1077 pg/ml;PPPConclusionsWe found that UCP sclerostin levels, birth weight, and placental weight were significant predictors of neonatal BMC but found no evidence for a main role of maternal levels of α-klotho, FGF23, sclerostin, or 25(OH)D nor of UCP levels of α-klotho, FGF23, or 25(OH)D. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|