Positron Emission Tomography Imaging Reveals Auditory and Frontal Cortical Regions Involved with Speech Perception and Loudness Adaptation
Autor: | Gert Joseph, Frank M. Bengel, Hubert H. Lim, Martin Mamach, Lilli Geworski, Minoo Lenarz, Thomas Lenarz, Cathleen Haense, Georg Berding, Geerd Meyer, Thilo Rode, Florian Wilke |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Adult
Male medicine.medical_specialty Speech perception Hearing loss lcsh:Medicine Audiology Stimulus (physiology) 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit Auditory cortex Loudness Hearing Loss Bilateral medicine otorhinolaryngologic diseases Humans Speech Prefrontal cortex lcsh:Science Electrodes Aged Auditory Cortex Brain Mapping Multidisciplinary business.industry lcsh:R Recovery of Function Middle Aged Adaptation Physiological Cochlear Implantation Cochlea Frontal Lobe Cochlear Implants medicine.anatomical_structure Acoustic Stimulation Frontal lobe Cerebral cortex Positron-Emission Tomography Speech Perception Female lcsh:Q medicine.symptom business Brain Stem Research Article |
Zdroj: | PLoS ONE, Vol 10, Iss 6, p e0128743 (2015) PLoS ONE |
Popis: | Considerable progress has been made in the treatment of hearing loss with auditory implants. However, there are still many implanted patients that experience hearing deficiencies, such as limited speech understanding or vanishing perception with continuous stimulation (i.e., abnormal loudness adaptation). The present study aims to identify specific patterns of cerebral cortex activity involved with such deficiencies. We performed O-15-water positron emission tomography (PET) in patients implanted with electrodes within the cochlea, brainstem, or midbrain to investigate the pattern of cortical activation in response to speech or continuous multi-tone stimuli directly inputted into the implant processor that then delivered electrical patterns through those electrodes. Statistical parametric mapping was performed on a single subject basis. Better speech understanding was correlated with a larger extent of bilateral auditory cortex activation. In contrast to speech, the continuous multi-tone stimulus elicited mainly unilateral auditory cortical activity in which greater loudness adaptation corresponded to weaker activation and even deactivation. Interestingly, greater loudness adaptation was correlated with stronger activity within the ventral prefrontal cortex, which could be up-regulated to suppress the irrelevant or aberrant signals into the auditory cortex. The ability to detect these specific cortical patterns and differences across patients and stimuli demonstrates the potential for using PET to diagnose auditory function or dysfunction in implant patients, which in turn could guide the development of appropriate stimulation strategies for improving hearing rehabilitation. Beyond hearing restoration, our study also reveals a potential role of the frontal cortex in suppressing irrelevant or aberrant activity within the auditory cortex, and thus may be relevant for understanding and treating tinnitus. |
Databáze: | OpenAIRE |
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