Anti-cancer properties of gastropodan hemocyanins in murine model of colon carcinoma
| Autor: | Andrey Tchorbanov, Iliyan Manoylov, Stela Chausheva, Vera Gesheva, Nikolina Mihaylova, Krassimira Idakieva, L. Doumanova |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_treatment
Snails Immunology Antineoplastic Agents Apoptosis chemical and pharmacologic phenomena Snail Cross Reactions Biology Rapana thomasiana Anti-cancer activity Immune system In vivo Cell Line Tumor biology.animal medicine Carcinoma Animals Mice Inbred BALB C Cancer Hemocyanin Helix pomatia Immunotherapy Flow Cytometry medicine.disease biology.organism_classification Survival Analysis Tumor Burden Disease Models Animal Phenotype Murine cancer model Antibody Formation Colonic Neoplasms Hemocyanins Cancer research Cytokines C-26 carcinoma Female Spleen Research Article |
| Zdroj: | BMC Immunology |
| ISSN: | 1471-2172 |
| Popis: | Background Various immunotherapeutic approaches have been used for the treatment of cancer. A number of natural compounds are designed to repair, stimulate, or enhance the immune system response. Among them are the hemocyanins (Hcs) - extracellular copper proteins isolated from different arthropod and mollusc species. Hcs are oxygen transporter molecules and normally are freely dissolved in the hemolymph of these animals. Hemocyanins are very promising class of anti-cancer therapeutics due to their immunogenic properties and the absence of toxicity or side effects. KLH (Megathura crenulata hemocyanin) is the most studied molecule of this group setting a standard for natural carrier protein for small molecules and has been used in anti-tumor clinical trials. Results The Hcs isolated from marine snail Rapana thomasiana (RtH) and the terrestrial snail Helix pomatia (HpH) express strong in vivo anti-cancer and anti-proliferative effects in the developed by us murine model of colon carcinoma. The immunization with RtH and HpH prolonged the survival of treated animals, improve humoral anti-cancer response and moderate the manifestation of C-26 carcinoma symptoms as tumor growth, splenomegaly and lung metastasis appearance. Conclusion Hemocyanins are used so far for therapy of superficial bladder cancer and murine melanoma models. Our findings demonstrate a potential anti-cancer effect of hemocyanins on a murine model of colon carcinoma suggesting their use for immunotherapy of different types of cancer. |
| Databáze: | OpenAIRE |
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