Effect of prostaglandin E in multiple experimental models. VII. Effect on resistance to sepsis
| Autor: | J. P. Waymack, Basil A. Pruitt, Arthur D. Mason, R. F. Guzman |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Prostaglandins E Synthetic medicine.medical_specialty medicine.medical_treatment Indomethacin Prostaglandin Critical Care and Intensive Care Medicine medicine.disease_cause Sepsis Mice Random Allocation chemistry.chemical_compound Internal medicine Escherichia coli Immune Tolerance medicine Animals Escherichia coli Infections Mice Inbred C3H business.industry Immunosuppression Biological activity General Medicine medicine.disease On resistance Disease Models Animal Endocrinology chemistry Immunology Emergency Medicine Surgery business Prostaglandin E |
| Zdroj: | Burns. 16:9-12 |
| ISSN: | 0305-4179 |
| DOI: | 10.1016/0305-4179(90)90198-6 |
| Popis: | The immunosuppression seen following burn injury has frequently been attributed to elevated prostaglandin E levels. We evaluated the contribution of elevated prostaglandin E levels on susceptibility to infectious complications utilizing multiple mouse models. The administration of 100 μg/kg of the long-acting derivative of prostaglandin E, 16,16-dimethyl-prostaglandin E, was found to improve survival in C3/HEN mice challenged with 1 × 10 8 Escherichia coli organisms intraperitoneally. The administration of indomethacin was found to decrease survival in the same model. With C3/HEJ (endotoxin-resistant) mice, indomethacin was found to increase mortality rates in animals challenged with 1 × 10 8 , 1 × 10 9 or 1 × 10 10 Escherichia coli organisms. These findings suggest that elevated prostaglandin E levels seen in burn patients may not be responsible for the postburn increased susceptibility to infectious complications. |
| Databáze: | OpenAIRE |
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