Sex Differences in Heart Failure With Preserved Ejection Fraction Reflected by B-type Natriuretic Peptide Level
| Autor: | Hirofumi Yasue, Yuji Mizuno, Hiroyuki Maeda, Naotsugu Yano, Eisaku Harada, Fumihito Kugimiya, Makoto Shono |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Population Physical examination 030204 cardiovascular system & hematology Muscle hypertrophy 03 medical and health sciences 0302 clinical medicine Sex Factors Internal medicine Natriuretic Peptide Brain Natriuretic peptide medicine Humans 030212 general & internal medicine education Aged Aged 80 and over Heart Failure education.field_of_study medicine.diagnostic_test business.industry Surrogate endpoint Stroke Volume General Medicine Plasma levels Middle Aged medicine.disease Heart failure Cardiology Female Heart failure with preserved ejection fraction business |
| Zdroj: | The American journal of the medical sciences. 356(4) |
| ISSN: | 1538-2990 |
| Popis: | Prevalence of heart failure with preserved ejection fraction (HFpEF) increases with advancing age, particularly among women. Plasma levels of B-type natriuretic peptide (BNP), a surrogate marker of heart failure, have consistently been shown to be higher in women in the general populations. Whether BNP levels differ as per the sex of HFpEF patients remains largely unknown.The study subjects were 733 HFpEF patients (204 men and 529 women, aged 80.9 ± 9.6 years) who underwent echocardiography and routine clinical examination, including plasma BNP level evaluation. These parameters were compared between women and men.Plasma levels of BNP were significantly lower in women than in men (104 [61, 192] versus 133 [78, 255] pg/mL, P0.001), just as hemoglobin, atrial fibrillation, diabetes mellitus, beta-blockers, left ventricular diastolic dimension, left ventricular mass index, left ventricular eccentric hypertrophy and left atrial dimension were. Age, systolic blood pressure, pulse pressure, heart rate, left ventricular relative wall thickness, left ventricular ejection fraction and left ventricular concentric hypertrophy were higher in women than in men. Multiple regression analyses revealed that left ventricular mass index, body mass index, the ratio of early diastolic mitral flow velocity to tissue annular motion velocity divided by left ventricular diastolic dimension, estimated glomerular filtration rate, beta-blockers, left atrial dimensions, female sex and atrial fibrillation were significant predictors for BNP levels (t = 5.41, P0.001; t = -4.06, P0.001; t = 3.76, P0.001; t = -3.68, P0.001; t = 3.32, P = 0.001; t = 3.11, P = 0.002; t = -3.07, P = 0.002; and t = 2.65, P = 0.008, respectively).Plasma BNP levels were lower in women and were related to left ventricular concentric remodeling and hypertrophy among HFpEF patients, contrary to those in the general population. |
| Databáze: | OpenAIRE |
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