Noradrenaline involvement in the memory-enhancing effects of exposure to a complex rhythm stimulus following discriminated passive avoidance training in the young chick
| Autor: | Nikki S. Rickard, Marie E. Gibbs, Samita Rachael Toukhsati, Kim T Ng, Eloise Perini |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Adrenergic beta-Antagonists Propranolol Stimulus (physiology) Arousal Discrimination Learning Behavioral Neuroscience chemistry.chemical_compound Norepinephrine Rhythm Memory Internal medicine medicine Avoidance Learning Animals Anisomycin Protein Synthesis Inhibitors Dose-Response Relationship Drug Uncoupling Agents Memoria Antagonist Age Factors Receptor antagonist Endocrinology chemistry Acoustic Stimulation Pattern Recognition Physiological Conditioning Operant Psychology 2 4-Dinitrophenol Chickens Photic Stimulation medicine.drug |
| Zdroj: | Behavioural brain research. 159(1) |
| ISSN: | 0166-4328 |
| Popis: | Previous research in our laboratory has demonstrated a significant memory-enhancing effect of exposure to a complex rhythm stimulus following weakly-reinforced passive avoidance learning in chicks. The aim of this study was to explore whether noradrenaline mediates this process. Chicks were trained on a strongly-reinforced single-trial passive avoidance task involving discrimination between two coloured beads. Intracerebral administration of the protein synthesis blocker, anisomycin, revealed that a phase of memory formation sensitive to arousal levels was extended by approximately 35 min following exposure to the complex rhythm stimulus. Administration of 2,4-dinitrophenol showed that this extension occurred during phase B of intermediate-term memory. Finally, a higher dose of the β-adrenergic receptor antagonist, propranolol, was required to inhibit long-term memory in the presence of the auditory stimulus than in its absence. These findings suggest that the memory-enhancing effects of the complex rhythm stimulus may be mediated by noradrenaline, possibly via an increase in physiological arousal. |
| Databáze: | OpenAIRE |
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