Biomarkers of oxidative-stress and inflammation in exhaled breath condensate from hospital cleaners

Autor: Marco Contoli, Barbara Bottazzi, Alice Vaccari, Alberto Papi, Michela Schito, Melissa Bonci, Piera Boschetto, Roberta Andreoli, Massimo Corradi, Mariarita Stendardo, Enrico Casimirri, Roberto Leone
Jazyk: angličtina
Rok vydání: 2015
Předmět:
0301 basic medicine
exhaled breath condensate
Health
Toxicology and Mutagenesis
Clinical Biochemistry
soluble interleukin-1 receptor type II
Biological effect markers
Pentraxin-3
cleaners
medicine.disease_cause
Biochemistry
Gastroenterology
chemistry.chemical_compound
0302 clinical medicine
Tandem Mass Spectrometry
Malondialdehyde
Surveys and Questionnaires
Ammonium Compounds
Exhaled breath condensate
Hydrogen peroxide
biology
Housekeeping
Hospital
Hydrogen-Ion Concentration
Middle Aged
Occupational Diseases
Serum Amyloid P-Component
C-Reactive Protein
Breath Tests
Exhalation
medicine.symptom
Adult
medicine.medical_specialty
Socio-culturale
Inflammation
Enzyme-Linked Immunosorbent Assay
03 medical and health sciences
Internal medicine
Occupational Exposure
medicine
Humans
Nitrites
Receptors
Interleukin-1 Type I
030201 allergy
Aldehydes
Nitrates
C-reactive protein
Hydrogen Peroxide
Ammonium compounds
respiratory tract diseases
Surgery
Oxidative Stress
030104 developmental biology
Cross-Sectional Studies
chemistry
biology.protein
Linear Models
Oxidative stress
Biomarkers
Popis: Objective: We studied the impact of chlorinated agents exposure on exhaled breath condensate (EBC) biomarkers in cleaners.Methods: Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrites (), nitrates (), pH, hydrogen peroxide (H2O2) and ammonium () were tested in EBC of 40 cleaners and 40 non-exposed controls. Pentraxin-3 (PTX3) and soluble type II receptor of IL-1 (sIL-1RII) were analyzed also in plasma.Results: Levels of MDA-EBC, 4-HNE-EBC and -EBC were higher, while pH-EBC values were lower, in cleaners. MDA-EBC was associated with 4-HNE-EBC, -EBC and pH. 4-HNE-EBC correlated with PTX3.Conclusion: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.
Databáze: OpenAIRE
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