Astrocytic Vesicle Mobility in Health and Disease
| Autor: | Nina Vardjan, Matjaž Stenovec, Saša Trkov, Mateja Gabrijel, Jernej Jorgačevski, Marko Kreft, Maja Potokar, Robert Zorec |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty amyotrophic lateral sclerosis glia Gliotransmitter Review Endocytosis multiple sclerosis Catalysis neuroinflammation Inorganic Chemistry lcsh:Chemistry astrocyte trafficking medicine Animals Humans Disease Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Neuroinflammation vesicle astrociti gliotransmitter multipla skleroza business.industry Secretory Vesicles Nervous tissue Vesicle Organic Chemistry Glutamate receptor Membrane Transport Proteins General Medicine Secretory Vesicle Computer Science Applications Cell biology antigen presentation medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Health Astrocytes udc:616-092 business glija Astrocyte |
| Zdroj: | International Journal of Molecular Sciences, Vol 14, Iss 6, Pp 11238-11258 (2013) International journal of molecular sciences, vol. 14, no. 6, pp. 11238-11258, 2013. International Journal of Molecular Sciences |
| ISSN: | 1422-0067 1661-6596 |
| Popis: | Astrocytes are no longer considered subservient to neurons, and are, instead, now understood to play an active role in brain signaling. The intercellular communication of astrocytes with neurons and other non-neuronal cells involves the exchange of molecules by exocytotic and endocytotic processes through the trafficking of intracellular vesicles. Recent studies of single vesicle mobility in astrocytes have prompted new views of how astrocytes contribute to information processing in nervous tissue. Here, we review the trafficking of several types of membrane-bound vesicles that are specifically involved in the processes of (i) intercellular communication by gliotransmitters (glutamate, adenosine 5'-triphosphate, atrial natriuretic peptide), (ii) plasma membrane exchange of transporters and receptors (EAAT2, MHC-II), and (iii) the involvement of vesicle mobility carrying aquaporins (AQP4) in water homeostasis. The properties of vesicle traffic in astrocytes are discussed in respect to networking with neighboring cells in physiologic and pathologic conditions, such as amyotrophic lateral sclerosis, multiple sclerosis, and states in which astrocytes contribute to neuroinflammatory conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|