Daidzein and genistein have differential effects in decreasing whole body bone mineral density but had no effect on hip and spine density in premenopausal women: A 2-year randomized, double-blind, placebo-controlled study
| Autor: | Lee Jane W. Lu, Fatima Nayeem, Manubai Nagamani, Nai Wei Chen, Karl E. Anderson |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
musculoskeletal diseases 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism Genistein chemistry.chemical_element Phytoestrogens 030209 endocrinology & metabolism Calcium Article Bone remodeling Placebos 03 medical and health sciences chemistry.chemical_compound Absorptiometry Photon 0302 clinical medicine Endocrinology Double-Blind Method Bone Density Internal medicine Humans Medicine Pelvic Bones Calcium metabolism Bone mineral Lumbar Vertebrae 030109 nutrition & dietetics Nutrition and Dietetics business.industry Daidzein Isoflavones Premenopause chemistry Female business |
| Zdroj: | Nutr Res |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/j.nutres.2019.06.007 |
| Popis: | Soy isoflavones are potentially beneficial phytoestrogens, but their tissue-selective effects in women are poorly understood. We tested the hypothesis that soy isoflavones affect bone mineral density (BMD), which may be influenced by individual differences in isoflavone metabolism and serum calcium levels. Ninety-nine healthy premenopausal women were randomized to isoflavones (136.6 mg aglycone equivalence) and 98 to placebo for 5 days per week for up to 2 years. BMD, serum calcium, and urinary excretion of daidzein and genistein were measured before and during treatment. In 129 adherent subjects, we found that isoflavone exposure, determined by urinary excretion levels, but not by dose assignment, interacted with serum calcium in affecting whole body BMD, but not hip and spine BMD. The regression coefficient was −0.042 for genistein excretion (GE) and 0.091 for the interaction between GE and serum calcium (all P |
| Databáze: | OpenAIRE |
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