Effect of pentobarbital on pH and electrolyte levels after induced seizure in rats
| Autor: | R. González-Piña, Pedro Sánchez-Aparicio, Daniel Mota-Rojas, María Alonso-Spilsbury, R. Uribe-Escamilla, Alfonso Alfaro-Rodríguez |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Male
Pentobarbital Sodium Clinical Neurology chemistry.chemical_element Electrolyte Pharmacology Calcium Statistics Nonparametric Electrolytes Animal model Seizures medicine High doses Animals Hypnotics and Sedatives Drug Interactions Rats Wistar Calcium metabolism General Medicine Carbamazepine Hydrogen-Ion Concentration Rats Disease Models Animal Neurology chemistry Pentylenetetrazole Anticonvulsants Neurology (clinical) medicine.drug |
| Zdroj: | Seizure. (5):397-401 |
| ISSN: | 1059-1311 |
| DOI: | 10.1016/j.seizure.2007.02.010 |
| Popis: | SummaryWe studied the effects of high doses of pentobarbital (PB) and carbamazepine (CBZ) on electrolyte levels and pH in an epileptic animal model. Pentobarbital decreased Ca2+ and Na+ levels without pentylenetetrazole (PTZ). After this, Ca2+ and Na+ levels continued to decrease except when CBZ was used, which preserved the Ca2+ levels PTZ may have opposed effects on PB. Our results suggest that PB causes changes in electrolyte levels and pH, but these changes are diminished by CBZ. |
| Databáze: | OpenAIRE |
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