Pregnancy and puerperium-related strokes in Asian women
| Autor: | Mohammad Saadatnia, Subhash Kaul, Narayanaswamy Venketasubramanian, Maria Khan, Padma Gunaratne, Mohammad Wasay, Man Mohan Mehndiratta, Bindu Menon, Alper I. Dai |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Pediatrics Asia Population Brain Ischemia Asian People Pregnancy Risk Factors Medicine Humans education Stroke Retrospective Studies education.field_of_study business.industry Incidence (epidemiology) Modified rankin score Rehabilitation Postpartum Period Hemorrhagic infarct Cerebral Arteries medicine.disease Cerebral Veins Surgery Pregnancy Complications Venous thrombosis Increased risk Treatment Outcome Female Neurology (clinical) Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 22(8) |
| ISSN: | 1532-8511 |
| Popis: | Despite an increased risk of stroke in pregnancy and puerperium, the overall incidence of the condition in this population is low. Therefore, there is limited data pertaining to these patients particularly from Asian countries. Our objective was to describe the risk factors and outcomes of 110 pregnancy-related ischemic strokes from 5 Asian countries.Data were collected by retrospective chart review in most cases and prospectively in the rest. Inclusion criteria for this subanalysis were women, pregnant or within 1-month postpartum, presenting to the study center with acute ischemic stroke (arterial or venous) confirmed by neuroimaging. Intracranial hemorrhages other than the ones associated with cerebral venous thrombosis or hemorrhagic infarct were excluded. Risk factors were diagnosed based on already published criteria. Outcomes were measured using modified Rankin score. Statistical analysis was done using Statistical Package for Social Sciences version 19.0.In all, 110 women with mean age of 27.94 years presented with pregnancy-related ischemic strokes; 58.2% of the strokes occurred postpartum and 49.1% were secondary to cerebral venous thrombosis. Venous strokes were significantly more likely to occur postpartum compared with arterial strokes (P=.01), to have abnormal "hypercoagulable panel result on admission" (P.001), less likely to have traditional stroke risk factors (P.001), to have hemorrhagic conversion of stroke (P.001), and to have lesser stroke severity and better functional outcome at 3 months (P.001 for each).Cerebral venous thrombosis is a significant contributor to pregnancy-related strokes in Asian women. Both traditional and pregnancy-specific risk factors should be addressed to control ischemic stroke risk in these women. |
| Databáze: | OpenAIRE |
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