Localized Requirements for windbeutel and pipe Reveal a Dorsoventral Prepattern within the Follicular Epithelium of the Drosophila Ovary
| Autor: | Trudi Schüpbach, Laura A Nilson |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Somatic cell
Mutant Genes Insect Biology Oogenesis Epithelium General Biochemistry Genetics and Molecular Biology Follicle medicine Animals Drosophila Proteins Body Patterning Polarity (international relations) Biochemistry Genetics and Molecular Biology(all) Egg Proteins Ovary Embryo Anatomy Embryonic stem cell Cell biology Phenotype medicine.anatomical_structure Mutation Insect Proteins Drosophila Female |
| Zdroj: | Cell. 93(2):253-262 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/s0092-8674(00)81576-7 |
| Popis: | Establishment of dorsoventral polarity within the Drosophila embryo requires extraembryonic positional information generated during oogenesis. The genes windbeutel, pipe, and nudel are required within the somatic follicle cells of the ovary for production of this spatial cue. Using a novel follicle cell marker system, we have directly evaluated the effect of mutant follicle cell clones on the embryonic dorsoventral pattern. We find no spatially localized requirement for nudel activity. In contrast, windbeutel and pipe are required only within a restricted ventral region of the follicular epithelium. This ventral region can determine lateral embryonic cell fates nonautonomously, indicating that spatial information originating ventrally is subsequently refined, perhaps via diffusion, to yield the gradient of positional information that determines the embryonic dorsoventral pattern. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|