Switching from Intravenous to Oral Tacrolimus Reduces its Blood Concentration in Paediatric Cancer Patients
| Autor: | Yoshiko Asakura, Naoyuki Nishiya, Shinpei Goto, Takeshi Chiba, Daishi Hirai, Haruki Ujiie, Mikiya Endo, Shoko Miura, Satoru Nihei, Kenzo Kudo, Shigeki Ito, Tatsuo Oyake |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Administration Oral chemical and pharmacologic phenomena Gastroenterology Pediatrics Tacrolimus Young Adult Paediatric cancer Oral administration Internal medicine Neoplasms Medicine Humans Child Aged business.industry Medical record Infant General Medicine Middle Aged medicine.disease Blood Physiological Phenomena Bioavailability Transplantation Haematopoiesis surgical procedures operative Graft-versus-host disease Oncology Child Preschool Administration Intravenous Female business |
| Zdroj: | Anticancer research. 41(5) |
| ISSN: | 1791-7530 |
| Popis: | Background/aim Tacrolimus is an essential immunosuppressant for successful allogeneic haematopoietic stem cell transplantation (Allo-HSCT). This study aimed to examine the change in the blood concentration of tacrolimus during switching from intravenous to oral administration in allo-HSCT for paediatric cancer to predict the optimal dosage. Patients and methods We retrospectively examined the medical records of 63 patients who received allo-HSCT and were administered tacrolimus. To compare bioavailability among different dose ranges, the blood concentration was divided by the dose (C/D). Results Thirty-nine patients (age range=children 1-15 years, adults 17-67 years) were switched to oral administration of tacrolimus. The C/D after switching was significantly lower in children than in adults (p=0.039). There was a strong positive correlation between age and C/D in children, whereas no correlation was observed in adults. Conclusion In paediatric cancer patients, switching tacrolimus administration route may result in reduced blood concentrations. This tendency is more prominent in younger children. |
| Databáze: | OpenAIRE |
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