Antitumor dendritic cell–based vaccines: lessons from 20 years of clinical trials and future perspectives
| Autor: | João Constantino, Amílcar Falcão, Bruno Miguel Neves, Maria Teresa Cruz, Célia Gomes |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biology Cancer Vaccines Food and drug administration 03 medical and health sciences 0302 clinical medicine Neoplasms Physiology (medical) Programmed cell death 1 Animals Humans Toll-like receptor Biochemistry (medical) Public Health Environmental and Occupational Health Dendritic Cells General Medicine Dendritic cell Clinical trial Dc vaccine 030104 developmental biology CTLA-4 Immunology Clinical value biology.protein Neuroscience 030215 immunology |
| Zdroj: | Translational Research. 168:74-95 |
| ISSN: | 1931-5244 |
| DOI: | 10.1016/j.trsl.2015.07.008 |
| Popis: | Dendritic cells (DCs) are versatile elements of the immune system and are best known for their unparalleled ability to initiate and modulate adaptive immune responses. During the past few decades, DCs have been the subject of numerous studies seeking new immunotherapeutic strategies against cancer. Despite the initial enthusiasm, disappointing results from early studies raised some doubts regarding the true clinical value of these approaches. However, our expanding knowledge of DC immunobiology and the definition of the optimal characteristics for antitumor immune responses have allowed a more rational development of DC-based immunotherapies in recent years. Here, after a brief overview of DC immunobiology, we sought to systematize the knowledge provided by 20 years of clinical trials, with a special emphasis on the diversity of approaches used to manipulate DCs and their consequent impact on vaccine effectiveness. We also address how new therapeutic concepts, namely the combination of DC vaccines with other anticancer therapies, are being implemented and are leveraging clinical outcomes. Finally, optimization strategies, new insights, and future perspectives on the field are also highlighted. |
| Databáze: | OpenAIRE |
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