Changes in Contractile Function with Low-Osmolal and Isosmolal Contrast Media for Coronary Angiography
| Autor: | Holten T, Per Jynge, Blankson H, Audun N. Øksendal |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cardiac function curve
Coronary angiography Contrast Media Coronary Angiography Ventricular Function Left 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Heart rate Animals Humans Medicine Radiology Nuclear Medicine and imaging Rats Wistar Iodixanol-320 Osmole Iotrolan Radiological and Ultrasound Technology business.industry Osmolar Concentration General Medicine Myocardial Contraction Iodixanol Rats 030220 oncology & carcinogenesis Iohexol business Nuclear medicine medicine.drug |
| Zdroj: | Acta Radiologica. 36:135-141 |
| ISSN: | 1600-0455 0284-1851 |
| DOI: | 10.1177/0284185195036s39916 |
| Popis: | Changes in contractile function induced by modern roentgen contrast media (CM) were examined in isolated rat hearts. Four coronary perfusions were undertaken in each heart with increasing volumes of each CM in order to test a wider spectrum of potential side-effects. Left ventricular developed pressure (LVDP) and heart rate (HR) were recorded. Six commercially available or investigational CM were examined: A, Hexabrix (ioxaglate 320 mg I/ml, Na 146 mM); B, Iosvist (iotrolan 300 mg I/ml, Na 6 mM);C, Visipaque (iodixanol 320 mg I/ml, Na 19 mM, Ca 0.3 mM); D, "Iodixanol high Ca-Mg" (iodixanol 320 mg I/ml, Na 19 mM, Ca 1.2 mM, Mg 0.6 MM); E, "Iohexol I 350" (iohexol 350 mg I/ml, Na 28 mM); and F, "Iohexol I 150" (iohexol 150 mg I/ml Na 28 mM). A, E and F were low-osmolal (400-940 mosm/kg H2O) CM whereas B, C and D were essentially isosmolal. Contractile changes (transient LVDP depression) was volume-dependent. Maximal values for LVDP depression were "Iohexol I 150" 11-22% |
| Databáze: | OpenAIRE |
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