Zinc Deficiency Increases Serum Concentrations of Parathyroid Hormone through a Decrease in Serum Calcium and Induces Bone Fragility in Rats
Autor: | Shin-ichi Katsumata, Yasutaka Kajita, Takako Suzuki, Kazuharu Suzuki, Hiroshi Matsuzaki |
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Rok vydání: | 2015 |
Předmět: |
Male
medicine.medical_specialty Deoxypyridinoline Osteocalcin Medicine (miscellaneous) Parathyroid hormone chemistry.chemical_element Calcium Bone and Bones Bone resorption Bone remodeling Random Allocation chemistry.chemical_compound Calcitriol Bone Density Internal medicine medicine Animals Magnesium Bone Resorption Rats Wistar Bone mineral Calcium metabolism Nutrition and Dietetics Chemistry Phosphorus medicine.disease Diet Rats Zinc Endocrinology Parathyroid Hormone Zinc deficiency |
Zdroj: | Journal of Nutritional Science and Vitaminology. 61:382-390 |
ISSN: | 1881-7742 0301-4800 |
Popis: | We hypothesized that a zinc-deficient diet alters the mineral (calcium, magnesium, and phosphorus) components of bones, as well as hormones related to bone remodeling, and negatively affects bone metabolism. Four-week-old male Wistar rats were randomly assigned to one of three groups for 4 wk: a zinc-adequate group (C, 30 ppm); a zinc-deficient group (ZD, 1 ppm); and a pair-fed group (PF, 30 ppm), which was pair-fed to the ZD group. Bone mineral density and bone mechanical properties were reduced in the ZD group compared to the C and PF groups. Compared with the C and PF groups, serum osteocalcin, a bone formation marker, was reduced in the ZD group. Conversely, urine deoxypyridinoline, a bone resorption marker, was increased in the ZD group compared to the C and PF groups. Calcium and phosphorus concentrations in bone were not different among all groups. The bone magnesium concentration was significantly higher in the ZD group than in the PF and C groups. Interestingly, compared with the C and PF groups, the ZD group showed a reduction in serum calcium concentration along with an increase in serum parathyroid hormone (PTH) concentration. Although serum 1,25-dihydroxycholecalciferol concentration was significantly higher in the ZD and PF groups than in the C group, the rate of apparent calcium absorption was significantly lower in the ZD group than in the C and PF groups. Therefore, zinc deficiency is suspected to cause an increase in serum PTH concentration owing to an inability to maintain calcium homeostasis, resulting in bone fragility. |
Databáze: | OpenAIRE |
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