Repeated clinical malaria episodes are associated with modification of the immune system in children
| Autor: | Magda E. Lotkowska, S Manni, Adam J. Reid, Mandy Sanders, E. P. de Villiers, Juliana Wambua, Philip Bejon, Chris I. Newbold, George Nyangweso, Mario Recker, Rhys M. Adams, John Joseph Valletta, Domtila Kimani, Y Bediako, Francis M. Ndungu, Kevin Marsh, Lin J-W., Addy Jwg., Jan Sodenkamp, Jean Langhorne, Joyce M. Ngoi, Jedidah Mwacharo, Matthew Berriman, O Kai |
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| Přispěvatelé: | University of St Andrews. Statistics |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_treatment
lcsh:Medicine E-NDAS Transcriptome 03 medical and health sciences 0302 clinical medicine Immune system SDG 3 - Good Health and Well-being parasitic diseases medicine Humans QR180 Immunology 030212 general & internal medicine Child Whole blood Systems immunology Immune activation business.industry lcsh:R General Medicine medicine.disease ddc Malaria 3. Good health Cytokine Immune System Diseases Child Preschool QR180 Cohort Immunology business 030217 neurology & neurosurgery CD8 Research Article |
| Zdroj: | BMC Medicine, Vol 17, Iss 1, Pp 1-14 (2019) BMC Medicine |
| ISSN: | 1741-7015 |
| Popis: | The study received funding from the UK Medical Research Council, (MRC Programme grant #: MR/M003906/1). MB and AR are supported by the Wellcome Trust (Grant #: WT 206194). Background There are over 200 million reported cases of malaria each year, and most children living in endemic areas will experience multiple episodes of clinical disease before puberty. We set out to understand how frequent clinical malaria, which elicits a strong inflammatory response, affects the immune system and whether these modifications are observable in the absence of detectable parasitaemia. Methods We used a multi-dimensional approach comprising whole blood transcriptomic, cellular and plasma cytokine analyses on a cohort of children living with endemic malaria, but uninfected at sampling, who had been under active surveillance for malaria for 8 years. Children were categorised into two groups depending on the cumulative number of episodes experienced: high (≥ 8) or low ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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