Primary leptomeningeal melanoma in a child
| Autor: | Juan A. Soult, Fatima Diaz-Fernandez, Miguel Muñoz, Rocio Barriga, José D. Lopez-Castilla |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Pathology medicine.medical_specialty Ataxia Diagnosis Differential Basal (phylogenetics) Meninges Cerebrospinal fluid Developmental Neuroscience Meningeal Neoplasms Humans Medicine Child Melanoma Coma medicine.diagnostic_test business.industry Leptomeninges Brain Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Hydrocephalus Neurology Pediatrics Perinatology and Child Health Neurology (clinical) medicine.symptom business |
| Zdroj: | Pediatric Neurology. 24:390-392 |
| ISSN: | 0887-8994 |
| DOI: | 10.1016/s0887-8994(01)00261-2 |
| Popis: | Primary malignant melanoma of the leptomeninges is a rare and aggressive tumor in children and accounts for less than 1% of all pediatric malignancies. Usually its symptoms include raised intracraneal pressure resulting from hydrocephalus secondary to tumoral obliteration of basal cisterns, but the passage of time from the initial symptomatology to diagnosis is frequently delayed. A 7-year-old male with primary leptomeningeal melanoma is reported. At the beginning, he presented ataxia and dysarthria followed by symptoms of raised intracranial pressure, complex partial seizures, progressive loss of consciousness, and coma. Cerebrospinal fluid analysis demonstrated raised opening pressure, normal glucose, and increased protein concentration, but malignant melanoma cells were not found. Magnetic resonance imaging scans depicted bright signals in the subarachnoid spaces on T(1) images and gadolinium-enhanced focal lesions. Cerebral biopsy was proposed, but it was not authorized. Definitive diagnosis was thus made by pathologic postmortem examination. |
| Databáze: | OpenAIRE |
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