Urban Air Pollution Particulates Suppress Human T-Cell Responses to Mycobacterium Tuberculosis
| Autor: | Hyejeong Choi, Raúl Quintana-Belmares, Srijata Sarkar, Stephan Schwander, Alvaro Osornio-Vargas, Olufunmilola Ibironke, Joyce Nwoko, Martha Torres, Claudia Carranza, Kathleen Black, Pamela Ohman-Strickland |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Tuberculosis
PM2.5 Health Toxicology and Mutagenesis medicine.medical_treatment T cell lcsh:Medicine 010501 environmental sciences T-bet 01 natural sciences Peripheral blood mononuclear cell M.tb Mycobacterium tuberculosis 03 medical and health sciences Immune system Immunity 11. Sustainability Medicine 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences biology business.industry lcsh:R Public Health Environmental and Occupational Health medicine.disease biology.organism_classification immunity 3. Good health Cytokine medicine.anatomical_structure 13. Climate action Immunology proinflammatory cytokines Tumor necrosis factor alpha business |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 16 Issue 21 International Journal of Environmental Research and Public Health, Vol 16, Iss 21, p 4112 (2019) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph16214112 |
| Popis: | Tuberculosis (TB) and air pollution both contribute significantly to the global burden of disease. Epidemiological studies show that exposure to household and urban air pollution increase the risk of new infections with Mycobacterium tuberculosis (M.tb) and the development of TB in persons infected with M.tb and alter treatment outcomes. There is increasing evidence that particulate matter (PM) exposure weakens protective antimycobacterial host immunity. Mechanisms by which exposure to urban PM may adversely affect M.tb-specific human T cell functions have not been studied. We, therefore, explored the effects of urban air pollution PM2.5 (aerodynamic diameters &le 2.5µ m) on M.tb-specific T cell functions in human peripheral blood mononuclear cells (PBMC). PM2.5 exposure decreased the capacity of PBMC to control the growth of M.tb and the M.tb-induced expression of CD69, an early surface activation marker expressed on CD3+ T cells. PM2.5 exposure also decreased the production of IFN-&gamma in CD3+, TNF-&alpha in CD3+ and CD14+ M.tb-infected PBMC, and the M.tb-induced expression of T-box transcription factor TBX21 (T-bet). In contrast, PM2.5 exposure increased the expression of anti-inflammatory cytokine IL-10 in CD3+ and CD14+ PBMC. Taken together, PM2.5 exposure of PBMC prior to infection with M.tb impairs critical antimycobacterial T cell immune functions. |
| Databáze: | OpenAIRE |
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