Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning
| Autor: | Chien-Hsiun Chen, Jer-Yuarn Wu, Ying Ju Lin, Fuu Jen Tsai, Henry Sung Ching Wong, Wei Chiao Chang, Hsing Fang Lu, Wen Ling Liao |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Genome-wide association study Adolescent Drug repositioning/repurposing Endocrinology Diabetes and Metabolism Clinical Biochemistry Druggability lcsh:Medicine 030209 endocrinology & metabolism Single-nucleotide polymorphism Computational biology Biology 03 medical and health sciences 0302 clinical medicine Drug Discovery Humans Pharmacology (medical) Genetic Predisposition to Disease Child Molecular Biology Gene Familial short stature Biomedicine Drug discovery business.industry Research Biochemistry (medical) lcsh:R Drug Repositioning Infant Newborn Computational Biology Infant Cell Biology General Medicine Body Height Drug repositioning 030104 developmental biology Pharmacogenomics Child Preschool Female business |
| Zdroj: | Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-12 (2019) Journal of Biomedical Science |
| ISSN: | 1423-0127 |
| Popis: | Background Genetic factors, dysregulation in the endocrine system, cytokine and paracrine factors are implicated in the pathogenesis of familial short stature (FSS). Nowadays, the treatment choice for FSS is limited, with only recombinant human growth hormone (rhGH) being available. Methods Herein, starting from the identification of 122 genetic loci related to FSS, we adopted a genetic-driven drug discovery bioinformatics pipeline based on functional annotation to prioritize crucial biological FSS-related genes. These genes were suggested to be potential targets for therapeutics. Results We discovered five druggable subnetworks, which contained seven FSS-related genes and 17 druggable targerts. Conclusions This study provides a valuable drug repositioning accompanied by corresponding targetable gene clusters for FSS therapy. |
| Databáze: | OpenAIRE |
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