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Tkachuk О. V., Tkachuk S. S., Povar M. A., Denysenko O. I., Shtefaniuk V. I. Violation in the axis of the "microbiota of the digestive tract-brain" under conditions of ischemia-reperfusion of the brain (literature review). Journal of Education, Health and Sport. 2021;11(05): 325-332. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.05.034 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.05.034 https://zenodo.org/record/5566922 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.05.2021. Revised: 21.05.2021. Accepted: 28.05.2021. VIOLATION IN THE AXIS OF THE "MICROBIOTA OF THE DIGESTIVE TRACT-BRAIN" UNDER CONDITIONS OF ISCHEMIA-REPERFUSION OF THE BRAIN (literature review) О. V. Tkachuk, S. S. Tkachuk, M. A. Povar, O. I. Denysenko, V. I. Shtefaniuk Bukovinian State Medical University, Chernivtsi, Ukraine Abstract The aim of the study is to analyze current views concerning interrelations between the state of intestinal microbiota and the course of ischemic-reperfusion brain injury. Conclusion. Literary data are indicative of disputable scientific opinions existing nowadays concerning the role of dysbacteriosis (neuroprotective or neurodegenerative) in the course of ischemic brain injuries. Meanwhile, the studies are in common concerning the evidenced role of the intestinal microbiota in disturbances of T-cell homeostasis, ratio changes of their Treg-Th17 subpopulations, and migration of intestinal lymphocytes to the ischemic brain. Key words: brain ischemia-reperfusion; intestinal microbiota; interrelations. |
