| Autor: |
Temitayo, Ajibade, Akinleye, Akinrinde, Moses, Adetona, Ademola, Oyagbemi, Aduragbenro, Adedapo, Christopher, Larbie, Temidayo, Omobowale, Olufunke, Ola-Davies, Adebowale, Saba, Adeolu, Adedapo, Oluwafemi, Oguntibeju, Momoh, Yakubu |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nigerian Journal of Physiological Sciences. 37:35-42 |
| ISSN: |
0794-859X |
| Popis: |
This study was designed to investigate the modulatory role of Luteolin (Lut), a flavonoid phytochemical, on haemodynamic parameters and the potential mechanisms involving renal Angiotensin II (AT2R) and Mineralocorticoid (MCR) receptors in renal toxicity induced by co-exposure to Diclofenac (Dcf) and sodium fluoride (NaF) in rats.Male Wistar rats were administered with either vehicle (control), Dcf only (9 mg/kg orally) or concurrently with NaF (300 ppm in drinking water). Other groups were treated with LutA (100 mg/kg) or LutB (200 mg/kg) along with Dcf and NaF exposures. All treatments lasted 8 days, following which blood pressure indices were measured using tail-cuff plethysmography. Renal expressions of AT2R and MCR were studied with immunohistochemistry, while biomarkers of oxidative and antioxidant status were also measured in the kidneys. Systolic, diastolic and mean arterial pressures were significantly (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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