Liver, NAFLD and COVID-19
| Autor: | Hoffmann, Carlotta, Gerber, Philipp A, Cavelti-Weder, Claudia, Licht, Louisa, Kotb, Reham, Al Dweik, Rania, Cherfane, Michele, Bornstein, Stefan R, Perakakis, Nikolaos |
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| Přispěvatelé: | University of Zurich |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Hormone and Metabolic Research. 54:522-531 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/a-1834-9008 |
| Popis: | Coronavirus disease 2019 (COVID-19) is characterized by a wide clinical spectrum that includes abnormalities in liver function indicative of liver damage. Conversely, people with liver diseases are at higher risk of severe COVID-19. In the current review, we summarize first the epidemiologic evidence describing the bidirectional relationship between COVID-19 and liver function/liver diseases. Additionally, we present the most frequent histologic findings as well as the most important direct and indirect mechanisms supporting a COVID-19 mediated liver injury. Furthermore, we focus on the most frequent liver disease in the general population, non-alcoholic or metabolic-associated fatty liver disease (NAFLD/MAFLD), and describe how COVID-19 may affect NAFLD/MAFLD development and progression and conversely how NAFLD/MAFLD may further aggravate a COVID-19 infection. Finally, we present the long-term consequences of the pandemic on the development and management of NAFLD. |
| Databáze: | OpenAIRE |
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