Synthetic and natural protease inhibitors provide insights into parasite development, virulence and pathogenesis
| Autor: | Rascón Aa, McKerrow Jh |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Proteases
Nematoda medicine.medical_treatment Virulence Biochemistry Aminopeptidases Immune system Cysteine Proteases Helminths parasitic diseases Drug Discovery medicine Animals Humans Protease Inhibitors Serpins Pharmacology Metalloproteinase Protease biology Organic Chemistry Entamoeba Helminth Proteins biology.organism_classification Cysteine protease Cystatins Cell biology Molecular Medicine Protozoa Cestoda Trematoda |
| Zdroj: | Current medicinal chemistry. 20(25) |
| ISSN: | 1875-533X |
| Popis: | Protease function is essential to many biological systems and processes. In parasites, proteases are essential for host tissue degradation, immune evasion, and nutrition acquisition. Helminths (worms) depend on several classes of proteases for development, host tissue invasion and migration, and for degradation of host hemoglobin and serum proteins. The protozoa, which cause malaria, depend on both cysteine and aspartic proteases to initiate host hemoglobin digestion. Other types of proteases are involved in erythrocyte cell invasion and cell exit. Surface metalloproteases in kinetoplastids are implicated in the evasion of complement-mediated cell lysis and cell entry. Cysteine proteases in Entamoeba facilitate invasion of the host colon. Giardia utilizes a cysteine protease for both encystation and excystation. This review will summarize published data using protease inhibitors as tools to identify the function of parasite proteases in the development, virulence, and pathogenesis of parasites; as well as the role of endogenous parasite protease inhibitors in regulation. |
| Databáze: | OpenAIRE |
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