Sleep characteristics and progression of coronary artery calcification : results from the Heinz Nixdorf Recall cohort study
| Autor: | Susanne Moebus, Bernd Kowall, A A Mahabadi, Thomas Budde, Dietrich Grönemeyer, Andreas Stang, Karl-Heinz Jöckel, Rainer Seibel, Raimund Erbel, Nils Lehmann, Anna-Therese Lehnich |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Sleep Wake Disorders medicine.medical_specialty Time Factors Computed Tomography Angiography Population Medizin Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Risk Assessment 03 medical and health sciences 0302 clinical medicine Risk Factors Germany Internal medicine Linear regression medicine Humans Longitudinal Studies Prospective Studies cardiovascular diseases Vascular Calcification education Aged education.field_of_study Recall business.industry Incidence Incidence (epidemiology) nutritional and metabolic diseases Middle Aged Sleep in non-human animals Confidence interval Coronary artery calcification Disease Progression cardiovascular system Cardiology Female Sleep Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Cohort study |
| Popis: | Sleep characteristics are associated with incident cardiovascular diseases (CVD), but there is a lack of studies on the association between sleep characteristics and incidence/progression of coronary artery calcification (CAC).In the Heinz Nixdorf Recall Study, a population-based cohort study in Germany, CAC was assessed by electron-beam tomography at baseline and at 5-year follow-up. In an analysis set of 3043 subjects (age at baseline 45-74 years; 47% men), we fitted logistic and linear regression models to assess associations between self-rated sleep characteristics (nocturnal and total sleep duration; napping; various sleep disorders) and CAC incidence/CAC progression. Progression was measured as 5-year progression factor, as categories of absolute CAC change, and additionally characterized as rapid or slow compared to an extrapolation of baseline CAC values.We observed barely any association between sleep characteristics and CAC progression regardless of the chosen statistical approach; associations between sleep and CAC incidence were slightly larger, e.g., the geometric mean of the 5-year CAC progression factor was 6.8% (95% confidence interval: -9.5; 25.9) larger for ≤5 h, 2.9% (-7.3; 14.3) larger for 5.1-6.9 h and 7.1% (-2.4; 15.7) smaller for ≥7.5 h total sleep compared to 7-7.5 h total sleep. For subjects with any regular sleep disorder, the geometric mean of the 5-year CAC progression was 3.5% (-4.7; 11.2) smaller compared to subjects without any regular sleep disorder.In this German cohort study, sleep characteristics were barely associated with CAC progression. |
| Databáze: | OpenAIRE |
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