An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines
| Autor: | Narsidas J. Parmar, Hitesh A. Barad, Rajni Kant, Bhavesh R. Pansuriya, Vivek K. Gupta |
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| Rok vydání: | 2012 |
| Předmět: |
Thiosemicarbazones
Antifungal Agents Magnetic Resonance Spectroscopy Pyrrolidines Clinical Biochemistry One-pot synthesis Antitubercular Agents Pharmaceutical Science Azomethine ylide Microbial Sensitivity Tests Crystallography X-Ray Biochemistry Microwave assisted Pyrrolidine chemistry.chemical_compound Candida albicans Gram-Negative Bacteria Drug Discovery Benzopyrans Microwaves Molecular Biology Molecular Structure Chemistry Aspergillus fumigatus Organic Chemistry Stereoisomerism Mycobacterium tuberculosis Combinatorial chemistry Cycloaddition Intramolecular force 1 3-Dipolar cycloaddition Molecular Medicine Azo Compounds Single crystal |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 22:4075-4079 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2012.04.070 |
| Popis: | An improved microwave assisted one-pot method for the synthesis of twelve new aryldiazenylchromeno [4,3-b] pyrrolidines via intramolecular azomethine ylide cycloaddition route is described. The method is efficient and advantageous over conventional and solvent-free thermal methods. The stereochemistry of the compounds was confirmed on the basis of various NMR experiments, and finally by single crystal X-ray diffraction data. N-Methyl or ethyl pyrrolidine based heterocycles gave good biological activities. |
| Databáze: | OpenAIRE |
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