Influence of Terminalia chebula on dermal wound healing in rats
| Autor: | Lonchin Suguna, Gowri Chandrakasan, Padmavathi Sampath, P Sivakumar, Surjeet Singh |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Staphylococcus aureus Antioxidant DPPH Administration Topical medicine.medical_treatment Pharmacognosy law.invention chemistry.chemical_compound In vivo law Klebsiella medicine Animals Skin Pharmacology Wound Healing integumentary system Lipid peroxide Traditional medicine Plant Extracts business.industry Hexosamines Anti-Bacterial Agents Rats Terminalia chebula Uronic Acids chemistry Terminalia Collagen Lipid Peroxidation Wound healing Phytotherapy business |
| Zdroj: | Phytotherapy Research. 16:227-231 |
| ISSN: | 1099-1573 0951-418X |
| DOI: | 10.1002/ptr.827 |
| Popis: | The effects of topical administration of an alcohol extract of the leaves of an evergreen plant, Terminalia chebula, on the healing of rat dermal wounds, in vivo, was assessed. T. chebula treated wounds healed much faster as indicated by improved rates of contraction and a decreased period of epithelialization. Biochemical studies revealed a significant increase in total protein, DNA and collagen contents in the granulation tissues of treated wounds. The levels of hexosamine and uronic acid in these tissues, also increased upto day 8 post-wounding. Reduced lipid peroxide levels in treated wounds, as well as ESR measurement of antioxidant activity by DPPH radical quenching, suggested that T. chebula possessed antioxidant activities. The tensile strength of tissues from extract-treated incision wounds increased by about 40%. In addition, T. chebula possessed antimicrobial activity and was active largely against Staphylococcus aureus and Klebsiella. These results strongly document the beneficial effects of T. chebula in the acceleration of the healing process. |
| Databáze: | OpenAIRE |
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