Healthcare-associated infections in high-risk neonates: Temporal trends in a national surveillance system
| Autor: | Lúcio Borges de Araújo, Sávia G.O. Melo, Vânia Olivetti Steffen Abdallah, Denise Von Dolinger de Brito Röder, Meliza Arantes de Souza Bessa, Felipe Flavio Silva, Murilo B. Oliveira, Nagela Bernadelli Sousa Silva, Reginaldo dos Santos Pedroso, Priscila Guerino Vilela Alves, Ralciane de Paula Menezes, Mário Paulo Amante Penatti |
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| Rok vydání: | 2021 |
| Předmět: |
Healthcare associated infections
Cross Infection medicine.medical_specialty Neonatal intensive care unit Bacteria business.industry Incidence Mortality rate Incidence (epidemiology) Infant Newborn Obstetrics and Gynecology Infection rate 03 medical and health sciences 0302 clinical medicine Intensive Care Units Neonatal 030225 pediatrics Internal medicine Pediatrics Perinatology and Child Health Epidemiological surveillance Humans Medicine Risk factor business Delivery of Health Care 030217 neurology & neurosurgery |
| Zdroj: | Early Human Development. 158:105394 |
| ISSN: | 0378-3782 |
| DOI: | 10.1016/j.earlhumdev.2021.105394 |
| Popis: | Background Increased survival of preterm neonates who require hospitalization at the Neonatal Intensive Care Unit has led to an increase in infections. This study aims to describe the temporal trend, risk factors, and outcome of healthcare-associated infections in a NICU of a high complexity hospital, with emphasis on the differences of incidence between bacterial and fungal infections. Methods The study was carried out from January 2013 to December 2016, with daily follow-up of the newborns by the National Healthcare Safety Network. Results The study included 881 newborns, of whom 214 had a bacterial infection, 19 had fungi infection, and 12 bacterial and fungal infections associated. The hospital infection rate was 12/1000 patient-days. SNAPPE>24, days of hospitalization and PICC days were independent risk factors for the development of fungal and bacterial infection, respectively, with statistical significance for bacterial and fungal infections. The mortality rate was 2.6 times higher in those who had fungal infection than in those who had a bacterial infection. The occurrence of invasive infections was higher in the years 2015 and 2016 and Gram-negative bacteria and yeasts were more frequent, impacting morbidity and mortality. Conclusions The use of invasive devices is a risk factor for the occurrence of HAI caused by bacteria and fungi. The frequency of deaths was higher in the group of neonates with fungal infection. These results point to the importance of constant epidemiological surveillance and measures of effective control of infections in NICU. |
| Databáze: | OpenAIRE |
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