Towards Neuro-CoViD-19
| Autor: | Francesco Chiappelli |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Central Nervous System (CNS) Central nervous system Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) Angiotensin-converting enzyme-2 receptor (ACE2-R) 03 medical and health sciences 0302 clinical medicine medicine Respiratory system Receptor Neuroinflammation biology business.industry fungi Neurodegeneration transmembrane protease serine-2 (TMPRSS2) Neurotoxicity Angiotensin-converting enzyme General Medicine medicine.disease Olfactory bulb Editorial 030104 developmental biology medicine.anatomical_structure Corona Virus Disease 2019 (CoViD-19) biology.protein business Neuroscience hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | Bioinformation |
| ISSN: | 0973-2063 0973-8894 |
| DOI: | 10.6026/97320630016288 |
| Popis: | CoViD-19 is the current pandemic caused by the Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). Infection by SARS-CoV-2 occurs via the binding of its S protein to the angiotensin-converting enzyme-2 receptor (ACE2-R). S binding to ACE2-R leads to a drop in ACE2, a homolog of angiotensin converting enzyme (ACE). In the central nervous system (CNS), ACE mediates neuroinflammation, neurodegeneration and neurotoxicity responsible for several CNS disorders. ACE2 counteracts the damaging effects of ACE on CNS neurons. SARS-CoV-2 can directly access the CNS via the circulation or via cranial nerve I and the olfactory bulb. Inactivation of ACE2 following binding of SARS-CoV-2 S protein to ACE2-R in situ might blunt ACE2-moderating effects upon ACE CNS neurotoxicity and neurodegeneration. Here, we propose a neurobiological mechanism directly involving SARS-CoV-2 binding to ACE2-R in the etiology of putative Neuro-CoViD-19. |
| Databáze: | OpenAIRE |
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