MiR-1273 g-3p Promotes Malignant Progression and has Prognostic Implications in Prostate Cancer
| Autor: | Qian Deng, Yaxue Chang, Yongyi Cheng, Zhenfeng Guan, Yi Sun |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Cell Bioengineering Applied Microbiology and Biotechnology Biochemistry Prostate cancer Cell Movement Cell Line Tumor Biomarkers Tumor Humans Medicine Stage (cooking) Molecular Biology Aged Cell Proliferation Neoplasm Staging Oncogene business.industry Proportional hazards model Cell growth Prostatic Neoplasms Cancer Middle Aged Prognosis medicine.disease Up-Regulation Survival Rate MicroRNAs medicine.anatomical_structure Cell culture Lymphatic Metastasis Cancer research business Biotechnology |
| Zdroj: | Molecular Biotechnology. 64:17-24 |
| ISSN: | 1559-0305 1073-6085 |
| Popis: | Prostate cancer (PCa) is the most popular cancer of mankind. Our study aimed to provide the expression and the predictive significance of miR-1273 g-3p in PCa. Moreover, the effects on cell biological activities were also investigated. The relative expression of miR-1273 g-3p in PCa tissues and cell lines was validated by quantitative real-time PCR. Kaplan-Meier curve and Cox regression analyses were performed to indicate the prognostic value. The implications of miR-1273 g-3p on cell proliferation, migration, and invasion were validated using the CCK-8 and Transwell assay. Our results provided that the expression of miR-1273 g-3p was increased in PCa tissues and cell lines. The levels of miR-1273 g-3p were associated with Gleason score, TNM stage, clinical stage, and lymph node metastasis. Overexpression of miR-1273 g-3p indicated a promising overall survival rate. Cox regression results indicated miR-1273 g-3p might be an independent marker for PCa patients. Silenced miR-1273 g-3p inhibited PCa cell proliferation, migration, and invasion. In total, miR-1273 g-3p was increased in PCa and identified as a therapeutic target and a prognostic factor for PCa patients. Overexpression of miR-1273 g-3p might be an oncogene via accelerating cell proliferation, migration, and invasion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink