An Autocrine/Paracrine Mechanism Triggered by Myocardial Stretch Induces Changes in Contractility

Autor: Horacio E. Cingolani, Néstor G. Pérez, María C. Camilión de Hurtado
Rok vydání: 2001
Předmět:
Zdroj: Physiology. 16:88-91
ISSN: 1548-9221
1548-9213
DOI: 10.1152/physiologyonline.2001.16.2.88
Popis: An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves release of angiotensin II, release/increased formation of endothelin, activation of the Na+/H+ exchanger, increase in intracellular Na+, and the increase in the Ca2+ transient that underlies the slow force response to stretch. The autocrine/paracrine mechanism could explain how changes in afterload alter cardiac contractility.
Databáze: OpenAIRE