An Autocrine/Paracrine Mechanism Triggered by Myocardial Stretch Induces Changes in Contractility
Autor: | Horacio E. Cingolani, Néstor G. Pérez, María C. Camilión de Hurtado |
---|---|
Rok vydání: | 2001 |
Předmět: |
medicine.medical_specialty
Physiology Chemistry Mechanism (biology) Myocardium Paracrine mechanism Autocrine paracrine Myocardial Contraction Angiotensin II Cell biology Contractility Autocrine Communication Endocrinology Internal medicine Paracrine Communication cardiovascular system medicine Animals Autocrine signalling Endothelin receptor |
Zdroj: | Physiology. 16:88-91 |
ISSN: | 1548-9221 1548-9213 |
DOI: | 10.1152/physiologyonline.2001.16.2.88 |
Popis: | An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves release of angiotensin II, release/increased formation of endothelin, activation of the Na+/H+ exchanger, increase in intracellular Na+, and the increase in the Ca2+ transient that underlies the slow force response to stretch. The autocrine/paracrine mechanism could explain how changes in afterload alter cardiac contractility. |
Databáze: | OpenAIRE |
Externí odkaz: |