LC-MS N-alkylamide Profiling of an Ethanolic Anacyclus pyrethrum Root Extract
| Autor: | Jente Boonen, Bart De Spiegeleer, Christian Burvenich, Vikas Sharma, Vinod Kumar Dixit |
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| Rok vydání: | 2012 |
| Předmět: |
Anacyclus pyrethrum
Spectrometry Mass Electrospray Ionization Polyunsaturated Alkamides Ultraviolet Rays Pyrethrum Pharmaceutical Science Asteraceae Mass spectrometry Plant Roots High-performance liquid chromatography Analytical Chemistry Liquid chromatography–mass spectrometry Drug Discovery Anacyclus Chromatography High Pressure Liquid Pharmacology Chromatography Ethanol Molecular Structure biology Plant Extracts Chemistry Organic Chemistry biology.organism_classification Complementary and alternative medicine Fatty Acids Unsaturated Molecular Medicine Anacyclus pyrethrum root extract |
| Zdroj: | Planta Medica. 78:1787-1795 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0032-1315371 |
| Popis: | An N-alkylamide profiling from an ethanolic Anacyclus pyrethrum DC. root extract was performed using a gradient reversed phase high performance liquid chromatography/UV/electrospray-ionization ion-trap mass spectrometry (HPLC/UV/ESI-MS) method on an embedded polar column. MS1 and MS2 fragmentation data were used for identification purposes while UV was used for quantification. Thirteen N-alkylamides (five N-isobutylamides, three N-methyl isobutylamides, four tyramides and one 2-phenylethylamide) were detected. Six of them, identified as undeca-2E,4E-diene-8,10-diynoic acid isobutylamide, undeca-2E,4E-diene-8,10-diynoic acid N-methyl isobutylamide, tetradeca-2E,4E-diene-8,10-diynoic acid tyramide, deca-2E,4E-dienoic acid N-methyl isobutylamide, tetradeca-2E,4E,XE/Z-trienoic acid tyramide and tetradeca-2E,4E,XE/Z,YE/Z-tetraenoic isobutylamide, are novel compounds which have never been reported before from Anacyclus pyrethrum. |
| Databáze: | OpenAIRE |
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