Randomised crossover trial to assess the tolerability of LHRH analogue administration
| Autor: | W G Bowsher, S Lindsay, G Williams |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Antineoplastic Agents Hormonal Urology Injections Subcutaneous Pain Pharmacology law.invention Prostate cancer Randomized controlled trial Leuprorelin law medicine Humans Patient comfort Aged Aged 80 and over Cross-Over Studies business.industry Goserelin Acetate Prostatic Neoplasms Middle Aged medicine.disease Crossover study Clinical trial Oncology Tolerability Delayed-Action Preparations Goserelin Leuprolide business medicine.drug |
| Zdroj: | Prostate cancer and prostatic diseases. 6(2) |
| ISSN: | 1365-7852 |
| Popis: | Luteinising hormone releasing hormone (LHRH) analogues are routinely used in the treatment of patients with advanced prostate cancer. This randomised crossover trial was conducted to compare patient comfort and tolerability between two commonly used LHRH analogues: goserelin acetate and leuprorelin acetate. A total of 50 patients were randomised into two groups, each receiving 6-monthly injections of leuprorelin acetate (a liquid presentation) and goserelin acetate (a depot pellet) and crossing over between treatments. Patients completed a simple visual analogue score for the discomfort felt from the injections. An analysis of variance model was used, and the results found that patients do tolerate leuprorelin acetate (0.589) better than goserelin acetate (1.343) (P < 0.001, CI = 95%). |
| Databáze: | OpenAIRE |
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