Exosome-depleted MiR-148a-3p derived from Hepatic Stellate Cells Promotes Tumor Progression via ITGA5/PI3K/Akt Axis in Hepatocellular Carcinoma
| Autor: | Xiangyu, Zhang, Feiyu, Chen, Peiran, Huang, Xinyu, Wang, Kaiqian, Zhou, Cheng, Zhou, Lei, Yu, Yuanfei, Peng, Jia, Fan, Jian, Zhou, Zuohua, Lu, Jie, Hu, Zheng, Wang |
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| Rok vydání: | 2022 |
| Předmět: |
Carcinoma
Hepatocellular Liver Neoplasms Cell Biology Exosomes Applied Microbiology and Biotechnology Gene Expression Regulation Neoplastic MicroRNAs Phosphatidylinositol 3-Kinases Cell Line Tumor Hepatic Stellate Cells Humans Proto-Oncogene Proteins c-akt Molecular Biology Ecology Evolution Behavior and Systematics Cell Proliferation Developmental Biology |
| Zdroj: | International Journal of Biological Sciences. 18:2249-2260 |
| ISSN: | 1449-2288 |
| Popis: | Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. Although it has been known that hepatic stellate cells (HSCs) play critical roles in the development and progression of HCC, the molecular mechanism underlying crosstalk between HSCs and cancer cells still remains unclear. Here, we investigated the interactions between HSCs and cancer cells through an indirect co-culture system. The expressions of cellular and exosomal miR-148a-3p were evaluated by quantitative real-time PCR. Cell counting kit-8 was used for evaluating cell growth |
| Databáze: | OpenAIRE |
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