Determinants of carotid atherosclerotic plaque burden in a stroke-free population
| Autor: | Wiro J. Niessen, Mariana Selwaness, Aad van der Lugt, Ronald van ‘t Klooster, Albert Hofman, Meike W. Vernooij, Quirijn J.A. van den Bouwhuijsen, Reinhard Hameeteman, Oscar H. Franco, Stefan Klein, Jolanda J. Wentzel |
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| Přispěvatelé: | Epidemiology, Medical Informatics, Radiology & Nuclear Medicine, Cardiology |
| Rok vydání: | 2016 |
| Předmět: |
Male
Comorbidity 030204 cardiovascular system & hematology Severity of Illness Index Rotterdam Study chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Risk Factors Carotid Stenosis Netherlands Aged 80 and over education.field_of_study medicine.diagnostic_test Smoking Middle Aged Lipids Magnetic Resonance Imaging Plaque Atherosclerotic Automated segmentation Carotid Arteries Plaque burden Predictive value of tests Cardiology Female Radiology Cardiology and Cardiovascular Medicine medicine.medical_specialty Population Hemorrhage 03 medical and health sciences Sex Factors Predictive Value of Tests Internal medicine Severity of illness Image Interpretation Computer-Assisted medicine Humans education Aged business.industry Magnetic resonance imaging medicine.disease Atherosclerosis Stenosis Plaque volume chemistry business Body mass index 030217 neurology & neurosurgery Carotid artery |
| Zdroj: | Atherosclerosis, 255, 186-192. Elsevier Ireland Ltd Atherosclerosis, 255 |
| ISSN: | 1879-1484 0021-9150 |
| Popis: | Background and aims In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. Methods The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer wall of the carotid arteries were automatically segmented and lumen volume (mm3), wall volume (outer wall–inner wall) and plaque burden (wall volume/outer wall volume) (%) were quantified. Plaque components were visually determined and luminal stenosis was assessed. We analyzed associations of cardiovascular risk factors and carotid plaque components with plaque burden and lumen volumes using regression analysis. Results We investigated 2821 carotid plaques and found that women had larger plaque burden (50.7 ± 7.8% vs. 49.2 ± 7.7%, p 3 vs. 1078 ± 334 mm3, p |
| Databáze: | OpenAIRE |
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