State of the Art in the Studies on Crotamine, a Cell Penetrating Peptide from South American Rattlesnake
| Autor: | Alexandre Pereira, Tetsuo Yamane, Paulo Luiz de Sá Júnior, André J. Zaharenko, Mirian A. F. Hayashi, Gandhi Rádis-Baptista, Alvaro R. B. Prieto da Silva, Irina Kerkis, Alexandre Kerkis |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Models
Molecular Cell Molecular Sequence Data lcsh:Medicine Venom Peptide Antineoplastic Agents Review Article Cell-Penetrating Peptides Biology General Biochemistry Genetics and Molecular Biology Cell Line Mice Anti-Infective Agents In vivo Crotalid Venoms medicine Animals Humans Amino Acid Sequence Peptide sequence Melanoma chemistry.chemical_classification General Immunology and Microbiology lcsh:R Crotalus General Medicine South America In vitro Crotamine medicine.anatomical_structure Biochemistry chemistry Immunology Cell-penetrating peptide |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Animal venoms comprise a naturally selected cocktail of bioactive peptides/proteins and other molecules, each of which playing a defined role thanks to the highly specific interactions with diverse molecular targets found in the prey. Research focused on isolation, structural, and functional characterizations of novel natural biologics (bioactive peptides/proteins from natural sources) has a long way to go through from the basic science to clinical applications. Herein, we overview the structural and functional characteristics of the myoneurotoxin crotamine, firstly isolated from the South American rattlesnake venom. Crotamine is the first venom peptide classified as a natural cell penetrating and antimicrobial peptide (CPP and AMP) with a more pronounced antifungal activity. In contrast to other known natural CPPs and AMPs, crotamine demonstrates a wide spectrum of biological activities with potential biotechnological and therapeutic values. More recent studies have demonstrated the selectivein vitroanticancer activity of crotamine.In vivo, using a murine melanoma model, it was shown that crotamine delays tumor implantation, inhibits tumor cells proliferation, and also increases the survival of mice engrafted with subcutaneous melanoma. The structural and functional properties and also the possible biotechnological applications of minimized molecules derived from crotamine are also discussed. |
| Databáze: | OpenAIRE |
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